Scientific Issues Associated with Prioritizing the Universe of Endocrine Disruptor Screening Program (EDSP) Chemicals Using Computational Toxicology Tools
The agency intends to screen those chemicals which have the greatest potential to interact with the endocrine systems in humans and other species. To that end, EPA has proposed an approach to determine the order in which to screen certain classes of chemicals (
e.g., drinking water contaminants and pesticide inert ingredients, including fragrances) using the Tier 1 battery under EPA’s Endocrine Disruptor Screening Program (EDSP). This proposed chemical prioritization process uses existing information including physicochemical properties and exposure information together with information from computational toxicology methods, including in silico expert systems, effects-based chemical category and read-across concepts, and empirical in vitro
low throughput and high throughput (HTP) testing. Thus, a number of specific current and emerging technical methods are involved in the proposed chemical prioritization process to cover the large EDSP chemical inventory
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