EPA’s EDSP 21 Work Plan responds to language in the proposed fiscal year 2012 budget for the agency, which states that “In FY 2012, EPA will begin a multi-year transition from the Endocrine Disruptor Screening Program (EDSP) to validate and more efficiently use computational toxicology methods and high throughput screens that will allow the agency to more quickly and cost-effectively assess potential chemical toxicity” (President’s Budget FY2012).

In response, the EDSP21 Work Plan describes an approach for using computational or in silico models and molecular-based in vitro high-throughput (HTP) assays to prioritize and screen chemicals to determine their potential to interact with the estrogen, androgen or thyroid (E, A, or T) hormonal systems.

In addition to complying with the Budget language, EPA believes that this new EDSP approach is consistent with the statutory requirement that EPA complete a first round of registration review of previously registered pesticides by October 1, 2022. Each review takes about 5 to 6 years. Currently, EPA initiates the review of approximately 70-80 active ingredients each year.

The EDSP 21 Work Plan is attached below