SAP Publishes Report on CompTox

The Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel met in Arlington, Virginia on January 29-31, 2013. This SAP reviewed a set of scientific issues associated with “Prioritizing the Universe of Endocrine Disruptor Screening Program (EDSP) Chemicals Using Computational Toxicology Tools”. The SAP’s report on this review is available by clicking here.
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SAP Meets on EDSP Tier 1 Evaluations

There will be a 4-day meeting of the Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel to consider and review Weight-of-Evidence: Evaluating Results of EDSP Tier 1 Screening. The meeting will be held July 30, 2013–August 2, 2013, from approximately 8:30 a.m. to 5 p.m., at the Environmental Protection Agency, Conference Center, Lobby Level, One Potomac Yard (South Bldg.), 2777 S. Crystal Dr., Arlington, VA 22202. Click here to read EPA’s Federal Register notice of this meeting.

EPA Changes Meeting Dates for EDSP Tier 1 SAP

EPA has changed the meeting dates of the Federal Insecticide, Fungicide, and
Rodenticide Act Scientific Advisory Panel that is reviewing EPA’s Endocrine Disruptor Screening Program Tier 1 Screening Assays and Battery Performance. The meeting was originally scheduled for May 21–24,
2013. The new meeting dates are May 21–23, 2013, from approximately 9 a.m.
to 5 p.m. The meeting will be held at the Environmental Protection Agency,
Conference Center, Lobby Level, One Potomac Yard (South Bldg.), 2777 S.
Crystal Dr., Arlington, VA 22202.

Click here to read EPA’s Federal Register notice changing meeting dates.

 

 

SAP Meeting on EDSP Tier 2 Tests

There will be a 4-day meeting of the Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel to consider and review proposed Endocrine Disruptor Screening Program Tier 2 Ecotoxicity Tests. The meeting will be held on June 25–28, 2013, from 9 a.m. to approximately 5:30 p.m. EPA encourages that written comments be submitted by June 11, 2013 and requests for oral comments be submitted by June 18, 2013. However, written comments and requests to make oral comments may be submitted until the date of the meeting, but anyone submitting written comments after June 11, 2013 should contact the Designated Federal Official  listed under FOR FURTHER INFORMATION CONTACT in the Agency’s Federal Register notice of this meeting. Click here to read EPA’s Federal Register notice.

How to Determine Data Quality?

One of the critical EDSP issues is how to determine whether EPSP test data are sufficiently accurate and reliable to be used for regulatory purposes. Determination of regulatory data quality was discussed by Dr. Richard Becker in a presentation at a recent National Toxicology Program webinar.  Dr. Becker’s presentation is well worth reading by anyone interested in this issue.

Click here to read Dr.  Becker’s presentation.

SAB Critically Reviews EPA’s Comptox

EPA’s Science Advisory Board met on March 7-8, 2013, to review several issues including EPA “Risk Assessments—Use of Computational Toxicology.” EPA hopes to use CompTox in several contexts, including the Agency’s Endocrine Disruptor Screening Program. Given its proposed EDSOP use, and the EPA Science Advisory Panel’s continuing review of CompTox, SAB Member Dr. Elaine Faustman pointed out that “[t]he review highlights in several contexts the significance of the early use of the CompTox data for screening dispersants in the Gulf however it is silent of the very large exercise of screening for endocrine disruption that is occurring as a part of the EPA endocrine screening program. Shouldn’t the review applaud EPA’s approach to emphasize the importance of such evaluations of Comp Tox results for current EPA needs?”

EDSP SAP Meets in May

There will be a 4-day meeting of the Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel to consider and review the Endocrine Disruptor Screening Program Tier 1 Screening Assays and Battery Performance. The meeting will be held on May 21 – 24, 2013, from approximately 9 a.m. to 5 p.m., at the Environmental Protection Agency,
Conference Center, Lobby Level, One Potomac Yard (South Bldg.), 2777 S. Crystal Dr.,
Arlington, VA 22202. EPA encourages that written comments be submitted by May
7, 2013, and requests for oral comments be submitted by May 14, 2013. However,
written comments and requests to make oral comments may be submitted until the date of
the meeting. Anyone submitting written comments after May 7, 2013 should contact
Fred Jenkins Jr., DFO, Office of Science Coordination and Policy (7201M), Environmental Protection Agency, 1200 Pennsylvania Ave., NW., Washington, DC 20460-0001; telephone number: (202) 564-3327; fax number: (202) 564-8382; email address: jenkins.fred@epa.gov

SAB Recommends that EPA Develop Data Use Guidelines for CompTox

On March 7, 2013, at 1:15 p.m., EPA’s Science Advisory Board will review the draft SAB Report “SAB Advice (1/29/13 Draft) on Advancing the Application of CompTox Research for Human Health Risk Assessment.” A copy of this draft report is available here.

This draft report includes several recommendations, one of which is that “EPA should develop data use guidelines for information generated by CompTox, including ExpoCast, for the various purposes to which it is intended.”

EPA SAB Meets on CompTox Reports

The Environmental Protection Agency’s Science Advisory Board will meet publicly on March 7, 2013, from 10:30 a.m. to 6:00 p.m. and Friday, March 8, 2013, from 8:00 a.m. to 1:00 p.m. The SAB will perform a number of reviews at this meeting. One of them is a quality review of three draft SAB reports on the use of computational toxicology to advance risk Assessment. The SAB meeting will be held at the Washington Marriott, 1221 22nd Street NW, Washington, DC, 20037.

EDSP Plans on Three More EDSP SAPs

On January 29-31, the FIFRA Science Advisory Panel reviewed EPA’s current efforts to prioritize the universe of Endocrine Disruptor Screening Program chemicals using computational toxicology tools.  At this SAP meeting, EPA representatives stated that the Agency intends to convene three more SAPs in 2013 to review EDSP issues.  According to EPA:

● the first additional SAP will review some “operational aspects” of the current EDSP tier 1 tests;

● the second additional SAP will review the validation status of the EDSP Tier 2 tests that EPA is developing; and

● the third additional SAP will review EPA’s Weight of Evidence analysis of the EDSP Tier 1 test results.

EPA did not provide the dates for these additional SAPs.