EPA Modifies Second List of EDSP Screening Chemicals

In November 2010, EPA developed a second list of chemicals for screening and draft policies and procedures for the Agency’s use to require testing of chemicals for Tier 1 screening. On June 14, 2013, EPA issued a revised second list of chemicals and revised policies and procedures for screening SDWA chemicals, including the statutory requirements associated with and format of the test orders, as well as EPA’s procedures for fair and equitable sharing of test costs and data confidentiality.

Update on EPA’s Endocrine Disruptor Screening Program

At the June 2014 meeting of the Pesticide Program Dialogue Committee, EPA presented an EDSP Update.  EPA’s PowerPoint presentation is available here.




SAP Meeting to Review New High Throughput Methods

There will be a 3-day meeting of the Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel to consider and review New High Throughput Methods to Estimate Chemical Exposure. The meeting will be held on July 29 to August 1, 2014, from approximately 9:00 a.m. to 5:00 p.m.  The meeting will be held at the EPA Conference Center, Lobby Level, One Potomac Yard (South Bldg.), 2777 S. Crystal Dr., Arlington, VA 22202.  EPA asks that written comments be submitted by July 15, 2014 and requests for oral comments be submitted by July 22, 2014. However, written comments and requests to make oral comments may be submitted until the date of the meeting. Click here for Meeting website.

PPDC Scheduled for EDSP Update

The Pesticide Program Dialogue Committee will meet June 5-6, 2014, at the EPA Conference Center, 2777 Crystal Drive (1 Potomac Yard South), Arlington, Virginia.  For those unable to attend in person, the Conference Line is 1-866-299-3188, and the Conference Code is 703 308 4775 #.  On June 6, from 10:45-11:15 ET, the PPDC is scheduled for an Endocrine Disruptor Screening Program Update.  The  Session Chair for this update is David Dix, Director, Office of Science Coordination and Policy, OCSPP, EPA.  Click here for the PPDC website.



NAS/NRC Publishes Review of EPA Paper on NMDRs

The National Academy of Science’s National Research Council has published its report entitled: Review of the Environmental Protection Agency’s State-of-the-Science Evaluation
of Nonmonotonic Dose–Response Relationships as They Apply to Endocrine Disruptors. This NAS/NRC report has obvious implications for EPA’s Endocrine Disruptor Screening Program.  Click here for report.

This report includes the following conclusions:

 “Recommendation: An analytic plan should be developed and applied consistently to the evidence on the three hormone pathways. Important elements of the plan include predefining and documenting the literature-search strategies and their results, establishing criteria for selecting studies for analysis, establishing criteria for determining study quality, using templates for presenting evidence consistently in tabular and graphic form, and documenting approaches to integration of evidence. Guidance on these elements is provided below [in following sections of the report].”

NAS Report on EPA and NMDR Now Scheduled for May 2014

The National Academy of Science’s National Research Council is reviewing EPA’s draft paper State of the Science on Nonmonotonic Dose Response.  This review has EDSP implications.  For example, some public comments to the Committee criticized EPA’s approach to the EDSP. Committee staff told CRE that publication of the Committee report on its review probably won’t occur until May 2014. The project website is available by clicking here.

EPA Beta Testing EDSP Online Response Module

EPA is developing a fully electronic, Web-based submission system to handle responses to future Endocrine Disruptor Screening Program  test orders.

During the week of April 21, 2014, EPA will be conducting Industry Beta Testing of the response module. This test will allow industry participants to access the test module and provide feedback on the response module prior to the tool’s launch. This feedback will be key to the successful development of this and future electronic submission systems. This beta testing was previously scheduled for the week of March 31, 2014.

NAS Hopes to Publish NMDR Report in April

The National Academy of Science’s National Research Council is reviewing EPA’s draft paper State of the Science on Nonmonotonic Dose Response.  This review has EDSP implications.  For example, some public comments to the Committee criticized EPA’s approach to the EDSP. Committee staff told CRE that the Committee hopes to publish a report on its review in April 2014. The project website is available by clicking here.

EPA Publishes New EDSP Comprehensive Management Plan

EPA’S new EDSP Management Plan was Jointly developed by the Agency’s Office of Chemical Safety & Pollution Prevention and the Office of Water.  According to EPA:

“This comprehensive management plan was developed by the EPA to describe activities envisaged between FY 2014 through FY 2019 and supersedes the original comprehensive management plan issued in June 2012; the management plan provides strategic guidance to the EPA staff and managers participating in the internal activities associated with EDSP. This comprehensive management plan does not create or confer legal rights or impose any legally binding requirements on the EPA or any other party. This comprehensive management plan is distributed solely for the purpose of sharing this information with the public, consistent with the EPA transparency objectives. It is not intended to serve any other purpose, and should not be construed to represent formal dissemination of any agency determination or policy. As such, the information correction process under the agency’s Information Quality Guidelines does not apply to this document.”

NIH Implements New Reproducibility Measures

Reproducibility of test results is an important EDSP issue.  The U.S. National Institutes of Health and Nature Magazine have announced new measures they are implementing to ensure reproducibility.  Click here to read about these new measures.