NAS Report on EPA and NMDR Now Scheduled for May 2014

The National Academy of Science’s National Research Council is reviewing EPA’s draft paper State of the Science on Nonmonotonic Dose Response.  This review has EDSP implications.  For example, some public comments to the Committee criticized EPA’s approach to the EDSP. Committee staff told CRE that publication of the Committee report on its review probably won’t occur until May 2014. The project website is available by clicking here.

EPA Beta Testing EDSP Online Response Module

EPA is developing a fully electronic, Web-based submission system to handle responses to future Endocrine Disruptor Screening Program  test orders.

During the week of April 21, 2014, EPA will be conducting Industry Beta Testing of the response module. This test will allow industry participants to access the test module and provide feedback on the response module prior to the tool’s launch. This feedback will be key to the successful development of this and future electronic submission systems. This beta testing was previously scheduled for the week of March 31, 2014.

NAS Hopes to Publish NMDR Report in April

The National Academy of Science’s National Research Council is reviewing EPA’s draft paper State of the Science on Nonmonotonic Dose Response.  This review has EDSP implications.  For example, some public comments to the Committee criticized EPA’s approach to the EDSP. Committee staff told CRE that the Committee hopes to publish a report on its review in April 2014. The project website is available by clicking here.

EPA Publishes New EDSP Comprehensive Management Plan

EPA’S new EDSP Management Plan was Jointly developed by the Agency’s Office of Chemical Safety & Pollution Prevention and the Office of Water.  According to EPA:

“This comprehensive management plan was developed by the EPA to describe activities envisaged between FY 2014 through FY 2019 and supersedes the original comprehensive management plan issued in June 2012; the management plan provides strategic guidance to the EPA staff and managers participating in the internal activities associated with EDSP. This comprehensive management plan does not create or confer legal rights or impose any legally binding requirements on the EPA or any other party. This comprehensive management plan is distributed solely for the purpose of sharing this information with the public, consistent with the EPA transparency objectives. It is not intended to serve any other purpose, and should not be construed to represent formal dissemination of any agency determination or policy. As such, the information correction process under the agency’s Information Quality Guidelines does not apply to this document.”

NIH Implements New Reproducibility Measures

Reproducibility of test results is an important EDSP issue.  The U.S. National Institutes of Health and Nature Magazine have announced new measures they are implementing to ensure reproducibility.  Click here to read about these new measures.

 

 

Central Data Exchange Registration Walkthrough for EDSP Test Order Recipients (Pesticides) – Tuesday, February 25, 2014

EPA is developing a fully electronic, Web-based submission system to handle receipt of responses to future EDSP test orders. Recipients of these orders will be required to register with and submit through the Central Data $xchange to use this system.On Tuesday, February 25, 2014, from 1:00 – 4:00 p.m. ET, EPA will be conducting, for pesticide stakeholders, a Web-based walk through of the registration process in preparation for these orders.  Please note that the focus of the session is on the registration process, and that specific reporting requirements will not be discussed during the demonstration.

ACC Center for Endocrine Screening and Testing

The American Chemistry Council operates a Center for Endocrine Screening and Testing.  This Center represents a premier scientific, technical, and advocacy resource for the chemical industry on endocrine issues, particularly in EPA’s EDSP. The wide range of services provided by the Center includes the following:

  • Consortium formation and management through CPTD
  • Interaction on behalf of members with EPA
  • Preparation of Requests for Proposal (RFP) and proposal solicitation from contract labs
  • Scheduling of testing to optimize other scientifically relevant information (OSRI), assay known performance, and limitations of testing protocols
  • Review OSRI to determine whether one or more EDSP Tier 1 screens can be omitted

EPA Provides EDSP Update

EPA representatives presented an EDSP update at the Pesticide Program Dialogue Committee meeting on December 5-6, 2014. Among other points, EPA stated the following:
“Based on current pace it could take decades to screen all 10,000 chemicals for potential to interact with the endocrine system.
Recent advances in computational toxicology herald an important ‘evolutionary turning point’ and an accelerated pace of screening and testing.
To address thousands of chemicals for potential to interact with the endocrine system, we must implement a more strategic approach to prioritize chemicals for targeted screening.”
Click here for EPA’s power point presentation.






				
				

Status of EDSP ICRs

In order to implement the EDSP, EPA needs OMB to approve Information Collection Requests under the Paperwork Reduction Act. EPA currently has three ICRs for the EDSP, and only one of them has been approved by OMB.

First, EPA has an approved ICR for Tier 1 screening of the first list of EDSP chemicals selected by EPA.  The OMB Control Number for this ICR is 2070-0176. The ICR Reference Number is 201210-2070-003. .  This ICR is approved with the following OMB Terms of Clearance:

NMDR Review Committee Considering Draft Report

The National Academy of Science’s National Research Council met on December 9-10, 2013, to review EPA’s draft paper State of the Science on Nonmonotonic Dose Response.  This was a closed meeting, and the public could not attend. According to the NAS/NRC project website, during this meeting the committee considered a Draft report and Draft findings and recommendations.  No written documents were made available to the committee in the meeting.  Click here for the project website.