SAP Meets on Integrated Endocrine Activity and Exposure-based Prioritization and Screening

There will be a 4-day meeting of the Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel (FIFRA SAP) to consider and review Integrated Endocrine Activity and Exposure-based Prioritization and Screening.

The meeting will be held on December 2-5, 2014, from approximately 9 a.m. to 5 p.m.  The meeting will be held at the Environmental Protection Agency, Conference Center, Lobby Level, One Potomac Yard (South Bldg.), 2777 S. Crystal Dr., Arlington, VA 22202.Show citation box

 EPA encourages that written comments be submitted by November 18, 2014, and requests for oral comments be submitted by November 25, 2014. However, written comments and requests to make oral comments may be submitted until the date of the meeting.

New Research Update Talks About ToxCast and NMDR

EPA has announced:

“The new Chemical Safety for Sustainability (CSS) Quarterly Research Update is now available. This issue features articles about innovative chemical research and highlights scientific awards, recent and upcoming events, employment opportunities and more.”

This research update includes articles on ToxCast and NMDR.

The CSS August Research Update can be access through this URL or by clicking on the image below.

 

ICCVAM Progress Report Availalble

The U.S. National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) has announced availability of the Interagency Coordinating Committee on the Validation of Alternative Methods Biennial Progress Report: 2012–2013. This report describes ICCVAM and ICCVAM agency activities during the period from January 2012 through December 2013.  This report was prepared in accordance with requirements of the ICCVAM Authorization Act of 2000 (42 U.S.C. 285l–3).

This report is available here.

 

 

NCATS Tox21 Data Challenge 2014

The National Center for Advancing Translational Sciences (NCATS) announces the Toxicology in the 21st Century (Tox21) Data Challenge 2014 competition. The Tox21 Data Challenge 2014 is a crowdsourcing competition to develop computational models that can better predict chemical toxicity. The Tox21 initiative is designed to improve current toxicity assessment methods, which are slow and costly.

Registration for the challenge and for more information, please click here.

The model submission deadline is Nov. 14, 2014, 11:59 p.m. ET. NCATS will showcase the winning models in January 2015.

EPA Modifies Second List of EDSP Screening Chemicals

In November 2010, EPA developed a second list of chemicals for screening and draft policies and procedures for the Agency’s use to require testing of chemicals for Tier 1 screening. On June 14, 2013, EPA issued a revised second list of chemicals and revised policies and procedures for screening SDWA chemicals, including the statutory requirements associated with and format of the test orders, as well as EPA’s procedures for fair and equitable sharing of test costs and data confidentiality.

Update on EPA’s Endocrine Disruptor Screening Program

At the June 2014 meeting of the Pesticide Program Dialogue Committee, EPA presented an EDSP Update.  EPA’s PowerPoint presentation is available here.

 

 

 

SAP Meeting to Review New High Throughput Methods

There will be a 3-day meeting of the Federal Insecticide, Fungicide, and Rodenticide Act Scientific Advisory Panel to consider and review New High Throughput Methods to Estimate Chemical Exposure. The meeting will be held on July 29 to August 1, 2014, from approximately 9:00 a.m. to 5:00 p.m.  The meeting will be held at the EPA Conference Center, Lobby Level, One Potomac Yard (South Bldg.), 2777 S. Crystal Dr., Arlington, VA 22202.  EPA asks that written comments be submitted by July 15, 2014 and requests for oral comments be submitted by July 22, 2014. However, written comments and requests to make oral comments may be submitted until the date of the meeting. Click here for Meeting website.

PPDC Scheduled for EDSP Update

The Pesticide Program Dialogue Committee will meet June 5-6, 2014, at the EPA Conference Center, 2777 Crystal Drive (1 Potomac Yard South), Arlington, Virginia.  For those unable to attend in person, the Conference Line is 1-866-299-3188, and the Conference Code is 703 308 4775 #.  On June 6, from 10:45-11:15 ET, the PPDC is scheduled for an Endocrine Disruptor Screening Program Update.  The  Session Chair for this update is David Dix, Director, Office of Science Coordination and Policy, OCSPP, EPA.  Click here for the PPDC website.

 

 

NAS/NRC Publishes Review of EPA Paper on NMDRs

The National Academy of Science’s National Research Council has published its report entitled: Review of the Environmental Protection Agency’s State-of-the-Science Evaluation
of Nonmonotonic Dose–Response Relationships as They Apply to Endocrine Disruptors. This NAS/NRC report has obvious implications for EPA’s Endocrine Disruptor Screening Program.  Click here for report.

This report includes the following conclusions:

 “Recommendation: An analytic plan should be developed and applied consistently to the evidence on the three hormone pathways. Important elements of the plan include predefining and documenting the literature-search strategies and their results, establishing criteria for selecting studies for analysis, establishing criteria for determining study quality, using templates for presenting evidence consistently in tabular and graphic form, and documenting approaches to integration of evidence. Guidance on these elements is provided below [in following sections of the report].”

NAS Report on EPA and NMDR Now Scheduled for May 2014

The National Academy of Science’s National Research Council is reviewing EPA’s draft paper State of the Science on Nonmonotonic Dose Response.  This review has EDSP implications.  For example, some public comments to the Committee criticized EPA’s approach to the EDSP. Committee staff told CRE that publication of the Committee report on its review probably won’t occur until May 2014. The project website is available by clicking here.